ACE inhibitors, angiotensin receptor antagonists and bradykinin.
نویسنده
چکیده
منابع مشابه
Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism.
One possible intervention to interrupt the deleterious effects of the renin-angiotensin system is suppression of angiotensin II (Ang II) formation by inhibition of angiotensin-converting enzyme (ACE). However, ACE inhibition incompletely suppresses Ang II formation and also leads to accumulation of bradykinin. Angiotensin II type 1 (AT1) receptors are believed to promote the known deleterious e...
متن کاملBradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade.
ACE inhibitors block B(2) receptor desensitization, thereby potentiating bradykinin beyond blocking its hydrolysis. Angiotensin (Ang)-(1-7) also acts as an ACE inhibitor and, in addition, may stimulate bradykinin release via angiotensin II type 2 receptors. In this study we compared the bradykinin-potentiating effects of Ang-(1-7), quinaprilat, and captopril. Porcine coronary arteries, obtained...
متن کاملBradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact?
The beneficial effect of ACE inhibitors in hypertension and heart failure may relate, at least in part, to their capacity to interfere with bradykinin metabolism. In addition, recent studies have provided evidence for bradykinin-potentiating effects of ACE inhibitors that are independent of bradykinin hydrolysis, i.e. ACE-bradykinin type 2 (B(2)) receptor 'cross-talk', resulting in B(2) recepto...
متن کاملAngiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-II and Val-HeFT?
JRAAS 2001;2:89–92 Introduction Certain drugs that block the renin-angiotensinaldosterone system (RAAS), namely angiotensin converting enzyme inhibitors (ACE-I) and spironolactone, have been shown to improve symptoms, reduce hospital admission rates and increase survival in patients with chronic heart failure (CHF). Consequently, angiotensin II (Ang II) type 1 receptor antagonists or Ang II typ...
متن کاملAngiotensin-converting enzyme inhibitors.
ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin II (Ang II) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other vasoactive substances. ACE inhibitors differ in the che...
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ورودعنوان ژورنال:
- Journal of the renin-angiotensin-aldosterone system : JRAAS
دوره 1 1 شماره
صفحات -
تاریخ انتشار 2000